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KMID : 0613820070170111593
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Journal of Life Science
2007 Volume.17 No. 11 p.1593 ~ p.1595
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Intestinal and Mesenteric Lymphosarcoma on Alcohol Liver Disease in the Mice
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Yuan Dong-Wei
Yang Hai-Jie
Hong Il-Hwa
Ki Mi-Ran
Park Jin-Kyu
Ku Moon-Jung
Lee Hye-Rim
You Sung-Eun
Jeong Kyu-Shik
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Abstract
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In the study of investigate the expression and effects of adrenomedullin (AM) in the tissue injured by ethanol in our laboratory, there were lymphosarcomas involving mesenteric lymph node and intestine discovered in experimental mice. Lymphosarcoma is probably the second most common spontaneous neoplastic disease, the incidence of which is dependent on the strain of mouse. The diagnosis of lymphosarcoma was based on gross and light microscopic studies. Grossly, the excised intestine and mesentery showed soft-to-firm, cream-colored, displayed protuberance into the lumen. The neoplastic cells had mainly infiltrated into the mucosal and mesenteric lymph node, and have round hyperchromatic nuclei and a small amount of cytoplasm. The origin of these tumor cells was determined by immunohistochemistry positive of CD20, CD3 and Vimentin.
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KEYWORD
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Intestine, mesentery, mice, lymphosarcoma
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